Valium

Valium is the trade name of the original medication Diazepam. This powerful tranquilizer (anxiolytic) belongs to the benzodiazepines class. It is an agonist of benzodiazepine receptors, located in the limbic system of the brain.

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Valium has a wide application in the medical field. In psychiatry, it is often prescribed to patients with a variety of mental illnesses, including depression, anxiety or panic disorder, and neurosis. The drug is also actively used in surgery and neurology for:

  • treatment of sleep disorders, associated with anxiety,
  • alleviating the symptoms of alcohol withdrawal,
  • treatment of spasticity in nerve damage,
  • reducing peripheral or cerebral spasms,
  • sedationprior to diagnostic or surgical procedures.

Valium belongs to potent tranquilizers with moderate abuse liability. Therefore, it is not recommended for reducing agitation, anxiety or stress, associated with persistent psycho-emotional discomfort.

For the symptomatic treatment of psychiatric or neurological diseases, modern health care professionals often prescribe Valium pills. They contain 2 mg, 5 mg or 10 mg of the active ingredient Diazepam. This drug is also available as a solution for injection at a dose of 5 mg/ml.

The action mechanism of Valium involves the release of GABA in the brain. This drug acts on various subtypes of benzodiazepine receptors in the limbic system. Thus, it has a wide range of therapeutic effects, including:

  • anticonvulsant - enhancing inhibition in the hippocampus receptors;
  • muscle relaxant - reducing the interneurons excitability in the CNS;
  • anxiolytic - by suppressing the activity of the amygdala complex receptors that are responsible for the emotional state of a person;
  • hypnotic and sedative - affecting the nonspecific nuclei of the thalamus, and reducing the activity of their neurons.

Therapeutic doses of Valium should be selectedindividually for each patient, depending on his age, diagnosis and symptoms intensity:

  • In psychiatry or neurology, adult patients are prescribed 2.5 mg of Valium one to three times a day. In low drug response, patients may take up to 15 mg of the drug per day, divided into 1-3 intakes.
  • To reduce the intensity of alcohol withdrawal symptoms, patients should take 10mg of Valium up to four times per day.
  • The maximum daily dose of this anxiolytic for the treatment of mental disorders is 60 mg for adults, and 5 mg - for the elderly or patients with low immunity.
  • The maximum dose of Valium for children weighing less than 25 kg is 22.5 mg per day, divided into three equal doses.
  • Patients with anxiety disorders are recommended to take 5-10 mg of this powerful anxiolytic 15 minutes before falling asleepto improve their sleep quality.

When patient takes additional doses for a prolonged time, Valium accumulates in the body. It can cause dizziness, weakness, and drowsiness, when used in high doses. To avoid side effects, take this anxiolytic in compliance with the assigned dosing regimen.

When administered orally on an empty stomach, Valium is absorbed and distributed throughout the body in about 15 minutes. The maximum plasma concentration of this anxiolytic is achievedin one to one and a half hours after oral administration.

Fatty food may slow down Valium absorption by approximately 30 minutes. The average half-life of this tranquilizer is 20 hours to 2 days.

The results of numerous randomized and comparative trials on Valium confirm that it helps to quickly cure the alcohol withdrawal symptoms or mental illnesses. Regular use of this drug helps eliminate the symptoms of such disorders, as:

  • tremor,
  • insomnia,
  • excitation,
  • hallucinations,
  • delirium tremens.

Today, Valium is one of the most popular anxiolytics of the benzodiazepines class. By its efficiency and safety, it is superior to drugs like Alprazolam (Xanax) or Estazolam (Prosom).